Sant Lab

Developing Biomimetic Microenvironments for Regenerative Therapies

Department of Pharmaceutical Sciences, University of Pittsburgh, PA





Find all our publications on 

 Goole scholar        Researchgate (.pdf available)     


Sant, S., Coutinho, DF., Gaharwar, AK., Neves, NM., Reis, RL., Gomes, ME., Khademhosseini A., Self‐Assembled Hydrogel Fiber Bundles from Oppositely Charged Polyelectrolytes Mimic Micro‐/Nanoscale Hierarchy of Collagen, Advanced Functional Materials, 2017.

Xue, Y., Hilaire, CS., Hortells, L., Phillippi, JA., Sant, V., Sant, S. Shape-Specific Nanoceria Mitigate Oxidative Stress-Induced Calcification in Primary Human Valvular Interstitial Cell Culture, Cellular and Molecular Bioengineering, 10, 5, 483-500.

Xue, Y., Balmuri, SR., Patel, A., Sant, V., Sant, S Synthesis, physico-chemical characterization, and antioxidant effect of PEGylated cerium oxide nanoparticles, Drug Delivery and Translational Research, 2017.

Sant, S., Johnston, PA.  The production of 3D tumor spheroids for cancer drug discoveryDrug Discovery Today: Technologies, 2017

Singh, M., Venkata Krishnan, H., Ranganathan. S., Kiesel, B., Beumer, JB., Sreekumar, S., Sant, S. Controlled Three-Dimensional Tumor Microenvironments Recapitulate Phenotypic Features and Differential Drug Response in Early vs Advanced Stage Breast Cancer, ACS Biomaterials Science & Engineering, 2017

Xue, Y., Yatsenko, A., Patel, A., Stolz, DB., Phillippi, JA., Sant, V., Sant, S PEGylated poly (ester amide) elastomer scaffolds for soft tissue engineering, Polymers for Advanced Technologies 2017.

Xue, Y., Sant, V., Phillippi, JA., Sant, S Biodegradable and biomimetic elastomeric scaffolds for tissue-engineered heart valvesActa Biomaterialia 48, 2–19.

Singh, M., Mukundan, S., Jaramillo. M., Oesterreich, S., Sant, SThree-dimensional breast cancer models mimic hallmarks of size-induced tumor progression, Cancer Research, June 2016 Volume 76, Issue 12

Patel, A., Sant, S. Hypoxic tumor microenvironment: Opportunities to develop targeted therapies, Biotechnology Advances, in press.

Patel, A., Xue, Y., Mukundan, S., Rohan, LC., Sant, V., Stolz, DB., Sant, S Cell-Instructive Graphene-Containing Nanocomposites Induce Multinucleated Myotube Formation, Annals of Biomedical Engineering, 2016 Jun;44(6):2036-48. 

Patel, A., Mukundan, S., Wang, W., Karumuri, A., Sant, V., Mukhopadhyay, SM., Sant, S Carbon-based hierarchical scaffolds for myoblast differentiation: Synergy between nano-functionalization and alignment, Acta Biomaterialia 32, 77–88.

Xue, Y., Patel, A., Sant, V.Sant, S,Semiquantitative FTIR Analysis of the Crosslinking Density of Poly (ester amide)‐Based Thermoset Elastomers, Macromolecular Materials and Engineering, 301, 3,296–305.

Xue, Y., Patel, A., Sant, V.Sant, SPEGylated poly(ester amide) elastomers with tunable physico-chemical, mechanical and degradation propertiesEuropean Polymer Journal. 72, 163-179

Mason, D., Chen, YZ., Harini, HV., Sant, S, Cardiac gene therapy: Recent advances and future directions, Journal of Controlled Release 215, 101-111

Singh, M., Close, DA., Mukundan, S., Johnston, PA., Sant, S., Production of Uniform 3D Microtumors in Hydrogel Microwell Arrays for Measurement of Viability, Morphology, and Signaling Pathway Activation, Assay and drug development technologies, 2015, Online Ahead of Print


Mukundan, S., Sant, V., Goenka, S., Franks, J., Rohan, LC., Sant, SNanofibrous composite scaffolds of poly (ester amides) with tunable physicochemical and degradation properties. European Polymer Journal 68, 21-35


Liu, H., Zhang, Z., Toh, WS., Ng, KW., Sant, S., Salgado, A., Stem Cells: Microenvironment, Micro/Nanotechnology, and Application. Stem cell International. April. 2015




Nanomaterials in Tissue Engineering: Fabrication and applications, Woodhead Publisher, Gaharwar, AK., Sant, S., Hacking, SA, Hancock, M. eds .


Sarkar, K., Xue, Y., Sant, S., Host Response to Synthetic Versus Natural Biomaterials In:The Immune Response to Implanted Materials and Devices, Springer International Publishing, 81-105


Sant, S., Coutinho, D., Sadr, N., Khademhosseini, A. Tissue-analogs by assembly of engineered hydrogel blocks In: Biomimetic approaches for biomaterial development, Joao F. Mano ed., Wiley-VCH, Verlag,GmBH.


Rabanel, J-M, Bertrand, B., Sant, S., Louati, S. and Hildgen, P., Polysaccharide hydrogels for the preparation of immunoisolated cell delivery systems In: Polysaccharides for drug delivery and pharmaceutical applications, Robert H. Marchessault, Francois Ravenelle And Xiao Xia Zhu Eds., American Chemical Society, Washington, ACS Symposium series no. 934, 2006, pp. 305-339.


Chen, Y, Sant, V., Sant, S, Anisotropic nanoparticles for drug delivery In: Nanoparticles for Biotherapeutic Delivery, Joshua D Ramsey and M Laird Forrest, Future Science Ltd. no.1, pp. 78-92


Sant, V., Goenka, S., Sant, S,, Emerging applications of graphene in drug and gene delivery In: In: Nanoparticles for Biotherapeutic Delivery, Joshua D Ramsey and M Laird ForrestFuture Science Ltd. no.2, pp. 104-116




Our research are presented in major important meetings & conferences!

SFB annual meeting

BMES annual meeting

MRS meeting

WBC 2016